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2019 Isitayela Esisha 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1

2019 Isitayela Esisha 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1

Incazelo emfushane:

I-CAS no:376591-94-5

Izakhiwo zamakhemikhali:I-Elthrombopag Intermediates


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Okuhlangenwe nakho okuchichima ngempela kokuphathwa kwamaphrojekthi kanye nemodeli eyodwa kuya koyedwa womhlinzeki kwenza kubaluleke kakhulu ukuxhumana kwenhlangano kanye nokuqonda kwethu kalula lokho okulindele ku-2019 Isitayela Esisha 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1, We bazimisele ukukunikeza inani eliphansi emakethe, ikhwalithi engcono kakhulu kanye nesevisi yokuthengisa enhle kakhulu.Siyakwamukela ukwenza ama-busines nathi, asiphumelele kabili.
Ulwazi oluningi ngempela lokuphatha amaphrojekthi kanye nemodeli eyodwa kuya koyedwa womhlinzeki kwenza kubaluleke kakhulu ukuxhumana kwenhlangano kanye nokuqonda kwethu kalula lokho okulindeleI-China 3-Aminopyrazine-2-Carboxylic Acid kanye ne-5424-01-1, Izimpahla zethu zithandwa kakhulu egameni, njengeNingizimu Melika, i-Afrika, i-Asia njalonjalo.Izinkampani "zokudala imikhiqizo yezinga lokuqala" njengomgomo, futhi zilwele ukunikeza amakhasimende izisombululo zekhwalithi ephezulu, ukunikeza isevisi yezinga eliphezulu emva kokuthengisa nokusekelwa kobuchwepheshe, kanye nokuhlomula kwamakhasimende ngokufanayo, ukudala umsebenzi ongcono nekusasa!

I-2′-Methoxy-3'-nitro-biphenyl-3-carboxylic acid isetshenziswa njengendawo emaphakathi ye-Eltrombopag.
I-Eltrombopag, eyakhiwe yi-GlaxoSmithKline (GSK) e-UK futhi kamuva yathuthukiswa ngokuhlanganyela ne-Novartis e-Switzerland, ingeyokuqala futhi iwukuphela kwe-molecule encane egunyazwe i-non-peptide TPO receptor agonist emhlabeni.I-Eltrombopag yagunyazwa yi-FDA yase-US ngo-2008 yokwelapha i-idiopathic thrombocytopenic purpura (ITP), nango-2014 ukuze kwelashwe i-aplastic anemia enzima (AA).Futhi isidakamizwa sokuqala esigunyazwe yi-US FDA sokwelapha i-AA eminyakeni engama-30 yakamuva.
Ngo-December 2012, i-US FDA yagunyaza i-Elthrombopag yokwelapha i-thrombocytopenia ezigulini ezine-hepatitis C (CHC) engapheli, ukuze iziguli ze-hepatitis C ezinokubikezelwa okungekuhle ngenxa yokubala kweplatelet ephansi zikwazi ukuqala futhi zilondoloze ukwelashwa okujwayelekile okusekelwe kwe-interferon kwezifo zesibindi.NgoFebhuwari3, 2014, i-GlaxoSmithKline yamemezela ukuthi i-FDA inikeze ukuphumelela komuthi wokwelapha i-Eltrombopag wokwelapha i-hemopenia ezigulini ezine-chemicalbook aplastic anemia (SAA) enzima kakhulu engazange iphendule ngokugcwele ku-immunotherapy.Ngomhla zingama-24 ku-Agasti, i-2015, i-US FDA igunyaze i-Eltrombopag yokwelashwa kwe-thrombocytopenia kubantu abadala kanye nezingane ezineminyaka engu-1 nangaphezulu ezine-immune immune thrombocytopenia (ITP) ezingenampendulo eyanele ku-corticosteroids, i-immunoglobulins noma i-splenectomy.NgoJanuwari4, 2018, i-Eltrombopag yagunyazwa ukuthi ifakwe ohlwini e-China ukuze zelashwe i-immune immune thrombocytopenia (ITP).

Okuhlangenwe nakho okuchichima ngempela kokuphathwa kwamaphrojekthi kanye nemodeli eyodwa kuya koyedwa womhlinzeki kwenza kubaluleke kakhulu ukuxhumana kwenhlangano kanye nokuqonda kwethu kalula lokho okulindele ku-2019 Isitayela Esisha 3-Aminopyrazine-2-Carboxylic Acid CAS No. 5424-01-1, We bazimisele ukukunikeza inani eliphansi emakethe, ikhwalithi engcono kakhulu kanye nesevisi yokuthengisa enhle kakhulu.Siyakwamukela ukwenza ama-busines nathi, asiphumelele kabili.
2019 Isitayela EsishaI-China 3-Aminopyrazine-2-Carboxylic Acid kanye ne-5424-01-1, Izimpahla zethu zithandwa kakhulu egameni, njengeNingizimu Melika, i-Afrika, i-Asia njalonjalo.Izinkampani "zokudala imikhiqizo yezinga lokuqala" njengomgomo, futhi zilwele ukunikeza amakhasimende izisombululo zekhwalithi ephezulu, ukunikeza isevisi yezinga eliphezulu emva kokuthengisa nokusekelwa kobuchwepheshe, kanye nokuhlomula kwamakhasimende ngokufanayo, ukudala umsebenzi ongcono nekusasa!


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