I-4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
I-4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
Isebenza ngokuvuselela i-central presynaptic alpha 2- receptors.Umphumela wayo we-hypotensive ufana nowe-nifedipine, i-calcium antagonist, ne-captopril, i-ACE inhibitor.Nge-hypertension ebalulekile.
Lo mkhiqizo kufanele wamukele isimiso somuthi ngamunye.Ngokuvamile qala kumthamo ophansi kakhulu, okungukuthi, 0.2mg, kanye ngosuku, othathwa ekuseni.Ukulungiswa kwemithamo kufanele kwenziwe ngezikhathi zamasonto amathathu kuze kutholakale imiphumela egculisayo.Umthamo ojwayelekile ngu-0.2mg kanye, kabili ngosuku (ekuseni nakusihlwa).Umthamo omkhulu ngesikhathi akumele udlule ku-0.4mg, futhi umthamo wansuku zonke omkhulu akufanele udlule i-0.6mg.Ezigulini ezinokwehluleka kwezinso okuncane noma okulinganiselwe, umthamo owodwa akufanele udlule ku-0.2 mg noma umthamo wansuku zonke akufanele udlule ku-0.4 mg.
Lo mkhiqizo uyi-α2-receptor agonist, okuyisidakamizwa se-imidazoline antihypertensive.Isetshenziselwa umfutho wegazi ophakeme ophakathi nendawo futhi oqinile.
Ngenxa yokuthi ivimbela ukukhishwa nokunyakaza kwepheshana lamathumbu, ibuye ifanele iziguli ezinomfutho wegazi ophakeme eziphethwe yizilonda zesilonda.Ukuhlanganiswa kwalo muthi kanye nama-diuretics kungathuthukisa kakhulu ukusebenza kahle.Iwumuthi onamandla omaphakathi we-antihypertensive kanye nomuthi we-antihypertensive womugqa wesibili.Isetshenziswa kakhulu endaweni ku-ophthalmology.Lo mkhiqizo unomphumela wokunciphisa ukucindezela kwe-intraocular, futhi akuphazamisi umshini wokulungisa umfundi kanye neso.Inganciphisa imithambo yegazi esweni, inciphise ukukhiqizwa kwamahlaya ane-aqueous, futhi ifinyelele umphumela wokunciphisa umfutho we-intraocular.Iqala ukusebenza emizuzwini eyi-15 ngemuva kokuwa kweso futhi ingagcina umphumela cishe amahora ayi-8.
Okujwayelekile:EP10
Okuqukethwe kwe-Assay:97.5-102.0%
Ingaphandle:Imhlophe noma icishe ibe yimpushana
Iphakheji:1kg/isikhwama noma njengoba kudingwa amakhasimende
I-JIN DUN Medical ineIziqu ze-ISO futhi ihlangabezana namazinga okukhiqiza e-GMP, kuqashwe ochwepheshe basekhaya nabangaphandle abanolwazi olunzulu lokuqondisa i-R&D yenkampani.
TECHNOL OGY UBUHLE
●I-High Pressure Catalytic Hydrogenation.I-High Pressure Hydrogenolysis Reaction .Ukusabela kwe-Cryogenic (<-78%C)
● I-Aromatic Heterocyclic Synthesis
●Ukusabela Kabusha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Ukusabela kukaGiignard
Izisetshenziswa
Ilebhu yethu inezinsiza ezihlukahlukene zokuhlola nokuhlola, njenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, i-Differential Scanning Calorimeter (DSC), i-Electron Microscope...
Ithimba le-R&D
I-Jindun Medical ineqembu labasebenzi abangochwepheshe be-R&D, futhi isebenzisa ochwepheshe abaningi bokwenziwa kwezidakamizwa basekhaya nabangaphandle ukuze baqondise i-R&D, okwenza ukuhlanganiswa kwethu kunembe kakhudlwana futhi kusebenze kahle.
Sisize izinkampani ezimbalwa eziphezulu zasekhaya ezithaka imithi, njengeI-Hansoh, i-Hengrui ne-HEC Pharm.Lapha sizokhombisa ingxenye yazo.
Ikesi Lokwenza Ngokwezifiso:
Inombolo yeCas: 110351-94-5
Ikesi Lokwenza Ngokwezifiso:
Inombolo yeCas: 144848-24-8
Ikesi Lesithathu Lokwenza Ngokwezifiso:
Inombolo yeCas: 200636-54-0
1.Enza ngendlela oyifisayo i-New Intermediates noma ama-API.Ngokufanayo nokwabelana kwecala elingenhla, amakhasimende anezidingo ze-Intermediates ethile noma ama-API, futhi awakwazi ukuthola imikhiqizo edingekayo emakethe, lapho-ke singasiza Ukwenza Ngokwezifiso.
2.Ukuthuthukisa Inqubo Yemikhiqizo Emidala.Ithimba lethu lizosiza Ukuthuthukisa futhi lithuthukise ukukhiqiza okunjalo okuyindlela yokusabela endala, izindleko zokukhiqiza ziphezulu, nokusebenza kahle kuphansi.Singahlinzeka ngemibhalo egcwele yokudluliswa kobuchwepheshe kanye nokuthuthukiswa kwenqubo, sisize ikhasimende ngokukhiqiza okuphumelelayo.
Ukusuka kokuhlosiwe kwezidakamizwa kuye kuma-IND, i-JIN DUN Medical ikunikezaizixazululo zomuntu siqu ze-R&D zokuma okukodwa.
I-JIN DUN Medical iphikelela ekwakheni iqembu elinamaphupho, ukwenza imikhiqizo enesizotha, ecophelelayo, eqinile, futhi siphume konke ukuze sibe uzakwethu othembekile nomngane wamakhasimende!
