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I-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

I-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7 Isithombe Esifakiwe
  • I-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

I-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

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Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukuze sibe yisiteji sokufeza amaphupho abasebenzi bethu!Ukuze wakhe iqembu elijabule, elihlangene nelingaphezulu lochwepheshe!Ukuze sifinyelele umvuzo ofanayo wabathengi bethu, abahlinzeki, umphakathi kanye nathi ngokwe-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Sithembekile futhi sivulekile.Sibheke phambili ekumiseni futhi simise ubudlelwano bothando obuthembekile nobuhlala isikhathi eside.
Ukuze sibe yisiteji sokufeza amaphupho abasebenzi bethu!Ukuze wakhe iqembu elijabule, elihlangene nelingaphezulu lochwepheshe!Ukuze sifinyelele umvuzo ofanayo wabathengi bethu, abahlinzeki, umphakathi kanye nathi ngokwethuI-China Pharmaceutical Intermediate kanye ne-330942-05-7, “Ikhwalithi enhle nenani eliphansi” yizimiso zethu zebhizinisi.Uma unentshisekelo ezisombululweni zethu noma unemibuzo, khumbula ukukhululeka ukusithinta.Sithemba ukusungula ubudlelwano bokusebenzisana nawe maduze nje.

I-Fondaparinux Biological Activity

Chaza I-Fondaparinux sodium iyi-antithrombin-dependent factor Xa inhibitor.
OkuhlobeneIzigaba indlela yesignali >> Ama-enzyme/amaphrotheni e-metabolic >> Izindawo zokucwaninga nge-Factor Xa >> Izifo zenhliziyo
Ithagethi I-Factor Xa[1]
In vitroizifundo I-Fondaparinux sodium iyi-anticoagulant yokuqala entsha eqondisa ngokukhetha i-factor Xa.Ku-Fondaparinux, inani le-IC50 (anti-Xa IU/ml) lama-monocyte acushiwe (ac-M) lingu-0.59±0.05, kanye nezinhlayiya ezitholakala ku-monocyte (MMP) ngu-0.17±0.03 [2].
Nge-vivoucwaningo I-Fondaparinux sodium inephrofayili ye-pharmacokinetic eqondile, encike kumthamo, enikeza impendulo ebikezelwe kakhulu.I-Fondaparinux sodium ine-bioavailability engu-100%, iqala ngokushesha ukusebenza, inesigamu sempilo yamahora angu-14 kuya kwangu-16, futhi ingaqhubeka nokumelana ne-thrombosis phakathi namahora angu-24.Umuthi asithinti isikhathi se-prothrombin noma isikhathi esicushiwe se-thromboplastin, futhi asithinti ukusebenza kweplatelet noma ukuhlanganisa [1].
Izithenjwa [1].Bauer KA.et al.I-Fondaparinux sodium: inhibitor ekhethiwe ye-factor Xa.Am J Health Syst Pharm.2001 Nov 1;58 Isengezo 2:S14-7.[2].Ben-Hadj-Khalifa S, et al.Umphumela ohlukile we-coagulation inhibitory we-fondaparinux, i-enoxaparin ne-heparin engahlukanisiwe kumamodeli wamaseli esizukulwane se-thrombin.Igazi Coagul Fibrinolysis.2011 Jul;22(5):369-73.

Izakhiwo zamakhemikhali nezomzimba ze-Fondaparinux

Ifomula yamangqamuzana I-C31H53N3Na10O49S8
Isisindo samangqamuzana 1738.16
I-PSA 900.82000

I-Fondaparinux iwuhlobo olusha lomuthi we-antithrombotic ogunyazwe yi-FDA ngemuva kwe-heparin kanye ne-heparin yesisindo esiphansi samangqamuzana okwelapha nokuvimbela izinhlobonhlobo ze-arteriovenous thrombosis.

Izinkomba: I-Fondaparinux isetshenziselwa iziguli ezihlinzwa kakhulu ngamathambo ezitho ezingezansi, njengokuphuka kwe-hip, ukuhlinzwa okukhulu kwamadolo noma ukushintshwa kwe-hip, ukuvimbela i-venous thromboembolism.Isetshenziselwa ukwelapha iziguli ezine-angina engazinzile noma i-non-segment elevation myocardial infarction ezithola ukwelashwa okuphuthumayo (ngaphansi kwemizuzu engu-120) (PCI) ngaphandle kwenkomba.Isetshenziselwa ukwelapha iziguli ezine-ST-segment elevation myocardial infarction ezisebenzisa i-thrombolysis noma ekuqaleni ezingatholi ezinye izinhlobo zokwelapha kabusha.

1）Ukuphromotha kwemakethe okuqhubekayo kuka-Glaxo kuzoyibeka endaweni eyinhloko yezidakamizwa endleleni elandelayo yomtholampilo yoMnyango Wezempilo, ukuguqulwa kwamanani entengo yeKhomishini Kazwelonke Yokuthuthukiswa Nezinguquko, kanye nomshwalense wezokwelapha woMnyango Wezomshuwalense Wabantu.

A, Umkhiqizo awukakangeni kumshwalense wezempilo kazwelonke.Ngo-2010, ukulungiswa komshwalense wezokwelapha kusanda kungena kumshwalense wendawo wezokwelapha wezifundazwe eziyi-16.Ukuthengisa kusesigabeni sokuqala futhi kancane kancane kuzongena esikhundleni semakethe ye-heparin enesisindo esiphansi;izifundazwe zomshuwalense wezokwelapha: Shaanxi, Shanxi, Inner Mongolia, Liaoning, Tibet, Yunnan, Guangdong , Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.

B, Izinkomba zisakhula.I-GSK njengamanje inezinkomba ezi-3 emtholampilo.Isibonelo, izinkomba zama-stents zigunyazwe kuphela.Amanye ama-heparin awatholakali.Ukusetshenziswa komtholampilo kwama-stents kukhuphuka ngo-30% njalo ngonyaka.Ngokugunyazwa kwezinkomba ezintsha, ukuthengisa kuzokhula.Ngokombono, zonke izifo eziphathwa ngemikhiqizo yochungechunge lwe-heparin zingelashwa yilo mkhiqizo.

C、Inzuzo yentengo, inani elincane lentengo yalo mkhiqizo emakethe yase-US ingamadola ayi-132 lilinye, eChina lingu-168 yuan, intengo yasekhaya ngeke yehle.Uma uthumela ngaphandle, imakethe yamazwe ngamazwe inendawo ebanzi;

2) Umkhawulo wezobuchwepheshe uphakeme, impahla eluhlaza ihlanganiswa ngezinyathelo ezingu-75, futhi ilungelo lobunikazi liphelelwe yisikhathi iminyaka engu-5 (i-athikili ngo-2014).Ayigunyazwanga abanye abakhiqizi.I-synthesis inzima kakhulu.Ngeke kwenziwe ngaphansi kweminyaka eyi-10.Umjikelezo mude, unzima, futhi utshale imali.phezulu.Bambalwa abancintisana nabo basekhaya, futhi izimbangi zakwamanye amazwe zinezindleko eziphezulu zempahla eluhlaza.Umgomo wethu uwukunciphisa ngokuqhubekayo izindleko zempahla eluhlaza futhi esikhundleni se-Glaxo ekukhiqizeni impahla eluhlaza.
I-Hengrui Pharmaceuticals Fondaparinux yavunywa njengokulingisa kokuqala e-China 2018.
I-Guangdong Runxing Biotechnology Co., Ltd. inomkhiqizo wonyaka wama-210 kg we-fondaparinux sodium advanced intermediate N3, ezofakwa ngo-2018.

I-Fondaparinux ekuqaleni yasungulwa yi-MYLAN IRELAND.Njengamanje, i-Hengrui Pharmaceuticals, i-Borui Pharmaceuticals, i-Haisco.

Ukuze sibe yisiteji sokufeza amaphupho abasebenzi bethu!Ukuze wakhe iqembu elijabule, elihlangene nelingaphezulu lochwepheshe!Ukuze sifinyelele umvuzo ofanayo wabathengi bethu, abahlinzeki, umphakathi kanye nathi ngokwe-MOQ Ephansi Yokuthengisa Okushisayo!I-Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Sithembekile futhi sivulekile.Sibheke phambili ekumiseni futhi simise ubudlelwano bothando obuthembekile nobuhlala isikhathi eside.
I-MOQ ephansi yeI-China Pharmaceutical Intermediate kanye ne-330942-05-7, “Ikhwalithi enhle nenani eliphansi” yizimiso zethu zebhizinisi.Uma unentshisekelo ezisombululweni zethu noma unemibuzo, khumbula ukukhululeka ukusithinta.Sithemba ukusungula ubudlelwano bokusebenzisana nawe maduze nje.

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