Okusanda Kufika 4-Biphenylcarboxylic Acid (92-92-2)

Ngokuphatha kwethu okuvelele, amandla obuchwepheshe anamandla kanye nenqubo yokubamba yekhwalithi ephezulu eqinile, siyaqhubeka nokunikeza abathengi bethu ikhwalithi enhle enokwethenjelwa, amanani okuthengisa anengqondo namasevisi amahle kakhulu.Sihlose ukuba ngokuqinisekile omunye wozakwethu abanomthwalo wemfanelo omkhulu futhi uzuze ukwaneliseka kwakho nge-Newly Arrival 4-Biphenylcarboxylic Acid (92-92-2), Umgomo wenhlangano yethu uwukunikeza njalo okuthengiswayo kwekhwalithi ephezulu, isevisi yochwepheshe, nokuxhumana okuthembekile. .Yamukela bonke abangani ukuze uthole isilingo sokwenza ubambiswano lwebhizinisi lwesikhathi eside.
Ngokuphatha kwethu okuvelele, amandla obuchwepheshe anamandla kanye nenqubo yokubamba yekhwalithi ephezulu eqinile, siyaqhubeka nokunikeza abathengi bethu ikhwalithi enhle enokwethenjelwa, amanani okuthengisa anengqondo namasevisi amahle kakhulu.Sihlose ukuthi sibe omunye wozakwethu abanomthwalo wemfanelo kakhulu futhi sizuze ukwaneliseka kwakhoI-China Organic Synthesis Intermediates, Izinto zethu ezithengiswayo zithunyelwa kakhulu eNingizimu-mpumalanga ye-Asia, eMpumalanga Ephakathi, eNyakatho Melika naseYurophu.Ikhwalithi yethu iqinisekisiwe.Uma unentshisekelo kunoma yiziphi izimpahla zethu noma ungathanda ukuxoxa nge-oda langokwezifiso, qiniseka ukuthi uzizwa ukhululekile ukusithinta.Sibheke ngabomvu ukwakha ubudlelwano bebhizinisi obuphumelelayo namakhasimende amasha emhlabeni jikelele esikhathini esizayo esiseduze.

I-2′-hydroxy-3′-nitro-3-biphenylcarboxylic acid isetshenziswa njengendawo emaphakathi ye-Eltrombopag.
I-Eltrombopag, eyakhiwe yi-GlaxoSmithKline (GSK) e-UK futhi kamuva yathuthukiswa ngokuhlanganyela ne-Novartis e-Switzerland, ingeyokuqala futhi iwukuphela kwe-molecule encane egunyazwe i-non-peptide TPO receptor agonist emhlabeni.I-Eltrombopag yagunyazwa yi-FDA yase-US ngo-2008 yokwelapha i-idiopathic thrombocytopenic purpura (ITP), nango-2014 ukuze kwelashwe i-aplastic anemia enzima (AA).Futhi isidakamizwa sokuqala esigunyazwe yi-US FDA sokwelapha i-AA eminyakeni engama-30 yakamuva.
Ngo-December 2012, i-US FDA yagunyaza i-Elthrombopag yokwelapha i-thrombocytopenia ezigulini ezine-hepatitis C (CHC) engapheli, ukuze iziguli ze-hepatitis C ezinokubikezelwa okungekuhle ngenxa yokubala kweplatelet ephansi zikwazi ukuqala futhi zilondoloze ukwelashwa okujwayelekile okusekelwe kwe-interferon kwezifo zesibindi.NgoFebhuwari3, 2014, i-GlaxoSmithKline yamemezela ukuthi i-FDA inikeze ukuphumelela komuthi wokwelapha i-Eltrombopag wokwelapha i-hemopenia ezigulini ezine-chemicalbook aplastic anemia (SAA) enzima kakhulu engazange iphendule ngokugcwele ku-immunotherapy.Ngomhla zingama-24 ku-Agasti, i-2015, i-US FDA igunyaze i-Eltrombopag yokwelashwa kwe-thrombocytopenia kubantu abadala kanye nezingane ezineminyaka engu-1 nangaphezulu ezine-immune immune thrombocytopenia (ITP) ezingenampendulo eyanele ku-corticosteroids, i-immunoglobulins noma i-splenectomy.NgoJanuwari4, 2018, i-Eltrombopag yagunyazwa ukuthi ifakwe ohlwini e-China ukuze zelashwe i-immune immune thrombocytopenia (ITP).

Ngokuphatha kwethu okuvelele, amandla obuchwepheshe anamandla kanye nenqubo yokubamba yekhwalithi ephezulu eqinile, siyaqhubeka nokunikeza abathengi bethu ikhwalithi enhle enokwethenjelwa, amanani okuthengisa anengqondo namasevisi amahle kakhulu.Sihlose ukuba ngokuqinisekile omunye wozakwethu abanomthwalo wemfanelo omkhulu futhi uzuze ukwaneliseka kwakho nge-Newly Arrival 4-Biphenylcarboxylic Acid (92-92-2), Umgomo wenhlangano yethu uwukunikeza njalo okuthengiswayo kwekhwalithi ephezulu, isevisi yochwepheshe, nokuxhumana okuthembekile. .Yamukela bonke abangani ukuze uthole isilingo sokwenza ubambiswano lwebhizinisi lwesikhathi eside.
Ukufika OkushaI-China Organic Synthesis Intermediates, Izinto zethu ezithengiswayo zithunyelwa kakhulu eNingizimu-mpumalanga ye-Asia, eMpumalanga Ephakathi, eNyakatho Melika naseYurophu.Ikhwalithi yethu iqinisekisiwe.Uma unentshisekelo kunoma yiziphi izimpahla zethu noma ungathanda ukuxoxa nge-oda langokwezifiso, qiniseka ukuthi uzizwa ukhululekile ukusithinta.Sibheke ngabomvu ukwakha ubudlelwano bebhizinisi obuphumelelayo namakhasimende amasha emhlabeni jikelele esikhathini esizayo esiseduze.