Izinga lokutholakala komdlavuza wendlala yesinye liyakhula unyaka nonyaka, futhi usungomunye wababulali abakhulu abathinta impilo yabesilisa asebekhulile.Njengamanje, i-China isungule izindinganiso ezicacile zokuhlola umdlavuza wendlala yesinye, kodwa kusadingeka ukuthi iqhubeke nokugqugquzela ukuthandwa kokuqwashisa ngokuhlolwa komphakathi.U-Ye Dingwei, iphini likamongameli weSibhedlela Somdlavuza esingaphansi kweFudan University kanye nenhloko yomnyango we-urology, uthe engqungqutheleni yakamuva yongoti besayensi yentuthuko yomdlavuza wendlala yesinye ebise-Guangzhou ukuthi i-China isadinga ukuqinisa indima yayo ehamba phambili ocwaningweni olusha lwezidakamizwa emhlabeni jikelele. ukuthuthukiswa kwezivivinyo zemitholampilo, ukuze kusheshiswe ukwanda kanye nokwethulwa kwemithi emisha futhi kuzuze iziguli eziningi eShayina.
Umdlavuza wendlala yesinye isimila esibi esiyingozi esenzeka ku-prostate futhi iyithumba eliyingozi elivame kakhulu ohlelweni lwe-urogenital wesilisa.Ngenxa yokuthi ayinazo izimpawu zomtholampilo eziqondile ekuqaleni, ngokuvamile odokotela noma iziguli benza iphutha nge-prostatic hypertrophy noma i-hyperplasia, futhi ngisho neziguli eziningi azifiki ukuzobona udokotela kuze kube yilapho zinezimpawu ze-metastatic ezifana nobuhlungu bethambo.Ngenxa yalokhu, cishe amaphesenti angama-70 eziguli ezinomdlavuza wendlala yesinye e-China zithuthuke kakhulu endaweni futhi zinomdlavuza osabalele we-metastatic uma sezitholakele, zingelashwa kahle kanye nokubikezelwa.Ngaphezu kwalokho, izinga lokutholakala komdlavuza wendlala yesinye likhula ngokuya ngeminyaka, likhuphuka ngokushesha ngemva kweminyaka engama-50, futhi izinga lokufa kwabantu abaneminyaka engu-85 ubudala lifinyelela inani eliphakeme kakhulu.Ngaphansi kwesizinda sokujula kokuguga eChina, inani eliphelele labantu abanomdlavuza wendlala yesinye eChina lizokhuphuka.
U-Ye Dingwei uthe izinga lokunyuka kwezinga lokutholakala komdlavuza wendlala yesinye eChina lidlule lelezinye izimila eziqinile, kanti nezinga lokufa nalo lenyuka kakhulu.Ngesikhathi esifanayo, izinga lokusinda kweminyaka emihlanu lomdlavuza wendlala yesinye eChina lingaphansi kwama-70%, kanti eYurophu nase-United States, ikakhulukazi e-United States, izinga lokusinda leminyaka emihlanu lisondele ku-100%.“Isizathu esikhulu salesi simo ukuthi ukuqwashisa ngokuhlolwa kwezwe lonke eChina kusebuthakathaka, futhi akukho ukuvumelana mayelana nokuqwashisa ukuthi amaqembu asengozini enkulu kufanele ahlolwe i-PSA njalo ngemva kweminyaka emibili;futhi ezinye iziguli azikakutholi ukuxilongwa nokwelashwa okujwayelekile, futhi lonke uhlelo lokulawula inqubo yomdlavuza wendlala yesinye eChina lusadinga ukuthuthukiswa.”
Njengemidlavuza eminingi, ukutholwa kusenesikhathi, ukuhlonzwa nokwelashwa komdlavuza wendlala yesinye kungakhuphula izinga lokusinda.UZeng Hao, oyilungu le-Youth Research Group kanye noNobhala-Jikelele we-Urology Branch ye-Chinese Medical Association, uthe abantu base-Europe nabaseMelika babheka kakhulu ukuvinjelwa nokwelashwa komdlavuza we-prostate, futhi izinga lokuhlolwa komdlavuza wendlala yesinye lilinganiselwe. okusezingeni eliphezulu, okuvumela iziguli eziningi ezinomdlavuza wangaphambi kwesikhathi we-prostate ukuthi zithole amathuba amahle okwelashwa, kuyilapho umphakathi waseShayina unolwazi oluncane ngokuhlolwa kwezifo, futhi iningi leziguli lithuthuke kakhulu endaweni kanye nomdlavuza wendlala yesinye we-metastatic osabalele lapho usutholakele.
“Kusenegebe elikhulu phakathi kweziguli zomdlavuza wendlala yowesilisa eChina kanye ne-Europe kanye ne-United States kusukela ekuqaleni kuya ekuxilongeni kuya ekwelashweni kuya ekubikezeleni.Ngakho-ke, ukuvinjelwa nokwelashwa komdlavuza wendlala yesinye eChina kusekude phambili,” kusho uZeng Hao.
Ungasishintsha kanjani isimo se-quo?U-Ye Dingwei uthe okokuqala wukuqhakambisa ukuqwashisa ngokuhlolwa kusenesikhathi.Iziguli ze-Prostate ezingaphezulu kweminyaka engama-50 ezisengozini enkulu kufanele zihlolelwe i-prostate specific antigen (PSA) njalo eminyakeni emibili.Okwesibili, ukwelashwa komdlavuza we-prostate kufanele kunake kakhulu ukwelashwa kokunemba kanye nomqondo wenqubo yonke.Okwesithathu, ekwelashweni, kufanele sinake i-multidisciplinary treatment (MDT) yeziguli ezinomdlavuza wendlala yesinye ezigabeni ezimaphakathi nezakamuva.Ngemizamo ehlanganyelwe yalezi zindlela eziningi ezingenhla, izinga lokusinda komdlavuza wendlala yesinye e-China lingase libe ngcono kakhulu esikhathini esizayo.
"Kusenendlela ende okufanele siyihambe ekuthuthukiseni izinga lokuxilongwa kusenesikhathi kanye nezinga lokunemba lokutholwa."UZeng Hao uthe ubunzima obukhulu ekuthuthukiseni ukuhlonzwa kusenesikhathi kanye nezinga lokwelashwa kusenesikhathi ukuthi ekusebenzeni komtholampilo, inani lama-tumor marker liyinkomba ebalulekile kuphela, futhi ukuhlonzwa kwesimila kudinga kuhlanganiswe ne-imaging noma i-puncture biopsy ukuze kuphelele. ukuxilongwa, kodwa iminyaka emaphakathi yeziguli ezinomdlavuza wendlala yesinye iphakathi kweminyaka engama-67 nengama-70 ubudala, Lolu hlobo lweziguli esezikhulile lunokwamukela okuphansi kwe-puncture biopsy.
Njengamanje, izindlela zokwelashwa ezijwayelekile zomdlavuza wendlala yesinye zibandakanya ukuhlinzwa, iradiotherapy, i-chemotherapy kanye nokwelashwa kwe-endocrine, phakathi kwayo i-endocrine therapy iyindlela yokwelapha eyinhloko yomdlavuza wendlala yesinye.
U-Ye Dingwei uthe imiphumela ye-ASCO-GU esanda kukhishwa kulo nyaka ibonise ukuthi ukwelashwa okuhlanganisiwe okuhlanganiswe ne-PARP inhibitor Talazoparib kanye ne enzalutamide kuzuze imiphumela emihle ocwaningweni lwesigaba sesi-III somtholampilo, futhi isikhathi sokusinda sisonke sithuthukiswe kakhulu, imiphumela elindelekile uma kuqhathaniswa, ngethemba lokuthuthukisa ikhwalithi yempilo yonke yeziguli ezinomdlavuza wendlala yesinye we-metastatic castration resistant prostate esikhathini esizayo.
“Asekhona amagebe ezimakethe kanye nezidingo zokwelashwa ezingakafinyeleli ekusungulweni kwemishanguzo emisha ezweni lethu.”U-Ye Dingwei uthe unethemba lokuthi uzosheshisa ukwethulwa kwemithi emisha, futhi unethemba lokuthi ithimba lezokwelapha laseShayina lingabamba iqhaza ocwaningweni lwezidakamizwa zomhlaba wonke, ligcine izinga elifanayo nocwaningo lwangaphandle kanye nentuthuko kanye nemakethe, futhi lisebenzisane ndawonye ukuletha okwengeziwe. izindlela ezintsha zokwelapha iziguli, ngcono izinga lokuxilonga kusenesikhathi kanye nokusinda sekukonke.
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Isikhathi sokuthumela: Mar-20-2023