Kuleli sonto, ijenali ephezulu yezemfundo i-Nature ishicilele iphepha lokucwaninga ku-inthanethi lethimba likaSolwazi Feng Liang eNyuvesi yase-Stanford, eliveza ukwakheka kanye nendlela esebenza ngayo ye-blood-brain brain-brain lipid transport protein MFSD2A.Lokhu kutholakala kusiza ukuklama izidakamizwa ukuze zilawule ukungena kwesithiyo sobuchopho begazi.
I-MFSD2A iyisithuthi se-phospholipid esibophezelekile ekuthathweni kwe-docosahexaenoic acid ebuchosheni kumaseli e-endothelial akha umgoqo wegazi nobuchopho.I-Docosahexaenoic acid yaziwa kangcono nge-DHA, ebalulekile ekuthuthukisweni nasekusebenzeni kobuchopho.Izinguquko ezithinta umsebenzi we-MFSD2A zingabangela inkinga yokukhula ebizwa ngokuthi i-microcephaly syndrome.
Ikhono lokuthutha i-lipid le-MFSD2A liphinde lisho ukuthi le phrotheni ihlobene eduze nobuqotho besithiyo sobuchopho begazi.Ucwaningo lwangaphambilini zithole ukuthi lapho umsebenzi walo uncishisiwe, umgoqo wegazi nobuchopho uzovuza.Ngakho-ke, i-MFSD2A ithathwa njengenguquko yokulawula ethembisayo lapho kudingekile ukweqa umgoqo wegazi nobuchopho ukuze ulethe imithi yokwelapha ebuchosheni.
Kulolu cwaningo, ithimba likaSolwazi Feng Liang lasebenzisa ubuchwepheshe be-cryo-electron microscopy ukuze lithole ukwakheka okuphezulu kokulungiswa kwegundane i-MFSD2A, lidalula isizinda salo esiyingqayizivele se-extracellular kanye ne-substrate ebopha imbobo.
Ukuhlanganisa ukuhlaziya okusebenzayo kanye nokulingiswa kokuguquguquka kwamangqamuzana, abacwaningi baphinde bahlonza iziza ezigciniwe zokubopha i-sodium esakhiweni se-MFSD2A, beveza izindlela ezingaba khona zokungena kwe-lipid, nokusiza ukuqonda ukuthi kungani ukuguqulwa okuthile kwe-MFSD2A kubangela i-microcephaly syndrome.
Isikhathi sokuthumela: Sep-01-2021