1.I-Shanghai yethule imithi yendabuko yamaShayina enegunya lobunikazi kanye namalungiselelo alula kanye nokwelashwa okungezona izidakamizwa ukuze kusizwe abantu balwe nomkhuhlane wasentwasahlobo.
I-Shanghai Municipal Administration of Traditional Chinese Medicine idalule ngomhlaka-5 ukuthi iNational Base for the Prevention and Control of Chinese Medicine Epidemic Diseases (Shanghai) ihole ekwakhiweni kwe-Chinese Medicine Prevention and Control Plan ye-2023 Spring Influenza e-Shanghai (Trial) (ngemuva kwalokhu okubizwa ngokuthi wuhlelo), iphakamise ukuqonda komuthi wamaShayina ngomkhuhlane, yenza imiyalelo yemithi yamaShayina yabantu abadala nezingane ngokusekelwe ekwehlukaniseni isifo, futhi yethula imithi eminingi yendabuko yamaShayina enegunya lobunikazi kanye namalungiselelo alula kanye nokwelashwa okungezona izidakamizwa ukuze kuvinjwe futhi kulawulwe umkhuhlane. .
Ebusika nasentwasahlobo, isimo sezulu sifudumele futhi siyabanda, umehluko wezinga lokushisa phakathi kwemini nobusuku uyashintshashintsha, futhi izifo ezithathelwanayo zonyaka zingene esikhathini esiphezulu kanye nenkathi yobhubhane.Muva nje, isibalo seziguli ezinomkhuhlane A nezinye izifo ezitholwe izibhedlela ezinkulu eShanghai senyukile.Uhlelo luhlose ukunikeza umdlalo ogcwele ezicini nasezinhlelweni zomuthi wendabuko waseShayina ekuvimbeleni nasekwelapheni umkhuhlane.
UZhang Wei, ongomunye wababhali balolu hlelo, isekela lomholi we-COVID-19 Expert Group for Traditional Chinese Medicine Treatment kanye nomqondisi woMnyango Wezifo Zokuphefumula esibhedlela iShuguang, ukholelwa ukuthi ukuthuthukiswa komkhuhlane (umkhuhlane) ikakhulukazi ukuzimela. ukukhawulela.Ezinye izingane ezibuthakathaka kanye nabantu asebekhulile abanezifo ezingaphansi zingabangela ezinye izinkinga ngenxa yezifo zangaphandle, okugxile ekuvimbeleni nasekwelapheni kwemithi yendabuko yaseShayina kanye nemithi yasentshonalanga.Utshele izintatheli ukuthi imithi yaseShayina ikholelwa ukuthi umkhuhlane ungaphansi kwesigaba samakhaza samanje.Ngokusho kokuqonda kwendabuko, ukuxilongwa nokwelashwa kusekelwe ikakhulukazi ohlelweni lokuhlukanisa i-syndrome nezindlela zokwelashwa zama-meridians ayisithupha, ukuhlukaniswa kwe-syndrome ye-Weiqi ne-Yingxue, kanye nesistimu yokuhlukanisa i-syndrome kanye nendlela yokwelapha ye-jiao emithathu, nokunaka. ikhokhelwa ekusetshenzisweni okuhlangene kokuqinisa nokuqeda izici ze-pathogenic ngezigaba nezigaba.
"Umkhuhlane uvame ukuzibekela umkhawulo futhi ungelapheka ngesikhathi esifushane ngemuva kokwelashwa okujwayelekile kwezimpawu kanye nokungenelela kwe-TCM."U-Zhang Wei uveze ukuthi, ngaphezu kwemithi yobunikazi bendabuko yamaShayina kanye namalungiselelo alula anconyiwe ohlelweni, izibhedlela ezinkulu ze-TCM e-Shanghai zinolwazi olucebile ekuxilongeni nasekwelapheni umkhuhlane, kanye nochungechunge lwamalungiselelo nemiyalelo yesibhedlela.
Kubikwa ukuthi ukudluliselwa kwakamuva ikakhulukazi i-H1N1.Uma uqhathaniswa nomkhuhlane ovamile, uyathelelana kakhulu, unezinga eliphakeme lomkhuhlane futhi uhlala isikhathi eside, unezimpawu ezisobala zesimiso, futhi unenkambo ende yezifo.
U-Xue Zheng, umbhali woHlelo Lwezingane kanye nomqondisi woMnyango Wezifo Zezingane wase-Shanghai Municipal Hospital of Traditional Chinese Medicine, ukholelwa ukuthi izingane ezingaphansi kweminyaka engu-5 ubudala zingangenwa umkhuhlane.Izingane zingenwa kalula umkhuhlane futhi ziba nezimpawu ezinzima ngenxa yamaphaphu azo athambile.Umuthi wendabuko waseShayina udlala indima enhle kakhulu ekuvimbeleni nasekwelapheni umkhuhlane ezinganeni, ikakhulukazi ekwelapheni umkhuhlane A, ongavimbela ukusabalala nokujula kwegciwane, uthuthukise ngokushesha izimpawu, futhi unobubanzi obubanzi.Izifo zezingane ezibhedlela ezinkulu zaseShayina naseNtshonalanga nazo zinamalungiselelo asesibhedlela avuthiwe asetshenziswa kabanzi emitholampilo.
Lolu hlelo lwenze isivumelwano somuthi wendabuko waseShayina kadokotela kanye nemithi yobunikazi yendabuko yamaShayina kanye namalungiselelo alula okwelashwa komkhuhlane wezingane, futhi lahlongoza nochungechunge lwezindlela zokwelapha zangaphandle ezilula nezingabizi zomuthi wesintu waseShayina.Abazali bangakwazi ukungenelela kwemithi yendabuko yamaShayina ngokusebenzisa izindlela zokwelapha zangaphandle ezifana ne-dietotherapy, i-massage, amaphuzu ezindlebe, ukufaka isicelo kanye nokwelapha okulenga impepho ukusiza izingane zithuthukise izimpawu ngokushesha futhi zilulame impilo ngokushesha ngangokunokwenzeka.
2.Abacwaningi besayensi bathola uchungechunge lwezithako ezisebenzayo ezilwa ne-hepatoma esitshalweni somuthi i-Artemisia annua.
I-Kunming Institute of Botany, i-Chinese Academy of Sciences, yamemezela ngomhla ka-21 ukuthi ithimba labacwaningi lika-Chen Jijun lithole uchungechunge lwenoveli yama-sesquiterpene dimers anomsebenzi wokulwa nomdlavuza wesibindi esitshalweni sezokwelapha i-Artemisia scoparia.Imiphumela yocwaningo efanelekile isanda kushicilelwa kujenali edume umhlaba wonke i-Signal Transmission and Targeted Therapy.
Umdlavuza wesibindi yisimila esiyingozi esisongela kakhulu impilo yabantu.Minyaka yonke, inani lamacala amasha omdlavuza wesibindi emhlabeni lidlula i-840000, futhi inani lokufa okubangelwa umdlavuza wesibindi lifinyelela ku-780000, kuyilapho cishe amaphesenti angu-50 amacala amasha e-China.Njengamanje, kune-tyrosine kinase inhibitors ezine, i-sorafenib, i-regafinil, i-lovatinib ne-cabotinib, i-vascular endothelial growth factor receptor 2 antagonist eyodwa, i-ramolumab, nama-PD-1 inhibitors amabili, i-navumab ne-pamuzumab, asetshenziswa ekwelapheni umdlavuza wesibindi. , kodwa uhlobo lwesakhiwo lulula futhi kulula ukukhiqiza ukumelana nemithi.
Eminyakeni yamuva nje, ithimba locwaningo lika-Chen Jijun lizibophezele ekufuneni izinhlanganisela eziholayo ze-anti-hepatoma kanye nezidakamizwa ezintsha ezinesakhiwo esiyingqayizivele kanye nendlela entsha yokusebenza evela ezitshalweni ze-Artemisia, futhi lisungule ngempumelelo indlela yokuhlukanisa ehlanganisa ukuqashelwa kokuqondisa kwe-sesquiterpene dimers e-Artemisia. izitshalo ezinokulandelela komsebenzi we-anti-hepatoma.Lolu cwaningo lwathola okokuqala ukuthi ukukhishwa kwe-Artemisia annua kunomsebenzi oqinile wokuvimbela amaseli amathathu e-hepatoma, futhi ngokokuqala ngqa, i-36 inoveli sesquiterpene dimers yezinhlobo ezingu-9 zesakhiwo - i-Artemisia annua A1-A3, B1-B2, C1-C4 , D, E, F1-F15, G1-G8, H kanye nami sahlukaniswa nengxenye esebenzayo ye-Artemisia annua.
Ucwaningo olwengeziwe lwabonisa ukuthi phakathi kwamanoveli angama-36 e-sesquiterpene dimers, umsebenzi we-artemisinin G5 kanye ne-G7 wawungcono kakhulu, owawulingana nesidakamizwa somtholampilo esilwa ne-hepatoma sorafenib somugqa wokuqala;Ukwengeza, i-artemisinin G7 eseningizimu ibonise ukukhetha nokuphepha okungcono kune-sorafenib ye-THLE-2 kumaseli esibindi avamile;Ngesikhathi esifanayo, i-artemisinin G7 eseningizimu ingavimbela ukwanda kwamaseli e-HepG2 ngokuvimbela ukuhlasela nokufuduka kwamaseli e-hepatoma, ibangele i-apoptosis futhi ivimbele umjikelezo weseli we-G2/M.
Lolu cwaningo lwembule ngokokuqala ngqa uchungechunge lwama-sesquiterpene dimers anamathambo anoveli kanye nesakhiwo esihlukahlukene e-Artemisia annua, lacebisa izinhlobo zesakhiwo se-sesquiterpene dimers ezitshalweni ze-Artemisia, futhi lwanikeza ama-molecule ahlukahlukene kanye nesisekelo esibalulekile sezokwelapha socwaningo lwe-anti entsha. -izidakamizwa ze-hepatoma.
Kuze kube manje, ithimba labacwaningi lika-Chen Jijun selihlukanise futhi likhombe amanoveli angama-122 ama-sesquiterpenoid dimers anomsebenzi wokulwa ne-hepatoma kusuka ku-Artemisia australis, Artemisia sinica, Artemisia medinalis, Artemisia cowtail kanye ne-Artemisia Mongolica, ebalelwa ku-52% yenani eliphelele le-disquiterpenoid engama-234 ebikwe ngu-234. Izitshalo ze-Artemisia emhlabeni.
I-JinDun Medicalinokubambisana kocwaningo lwesayensi yesikhathi eside kanye nokuxhunyelelwa kwezobuchwepheshe namanyuvesi aseShayina.Ngezinsiza zezokwelapha ezicebile ze-Jiangsu, inobudlelwano besikhathi eside bokuhwebelana ne-India, i-Southeast Asia, iNingizimu Korea, iJapan nezinye izimakethe.Iphinde inikeze izinsizakalo zemakethe nezokuthengisa kuyo yonke inqubo kusukela ku-API yomkhiqizo omaphakathi kuya oqediwe.Sebenzisa izinsiza eziqoqiwe ze-Yangshi Chemical kukhemistri ye-fluorine ukuze unikeze izinsizakalo ezikhethekile zokwenza amakhemikhali ngokwezifiso kozakwethu.Nikeza inqubo emisha kanye nezinsizakalo zocwaningo lokungcola ukuze uqondise amakhasimende.
I-JinDun Medical iphikelela ekudaleni iqembu elinamaphupho, lenze imikhiqizo enesithunzi, ecophelelayo, eqinile, futhi iphume konke ukuze ibe uzakwethu othembekile kanye nomngane wamakhasimende! professionalukukhiqizwa kwemithi ngokwezifiso(i-CMO) kanye nabahlinzeki besevisi be-R&D bezemithi kanye nokukhiqiza (CDMO).
Isikhathi sokuthumela: Mar-30-2023