I-Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6

Sinalesi siqubulo, manje sesibe phakathi kwabakhiqizi okungenzeka ukuthi bathuthuke kakhulu kwezobuchwepheshe, abangabizi kakhulu, nabancintisana namanani e-Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Sibheke ngabomvu ukukunikeza ngemikhiqizo yethu maduze nje, futhi uzothola ikhotheshini yethu inengqondo futhi nezinga lemikhiqizo yethu lihle kakhulu!
Sinalesi siqubulo emqondweni, manje sesibe phakathi kwabakhiqizi abangaba namasu amasha kwezobuchwepheshe, abangabizi kakhulu, futhi abancintisana namanani entengo.I-China Ibrutinib N-3 kanye nabaPhakathi, Kuze kube manje imikhiqizo yethu isithunyelwe empumalanga Yurophu, eMpumalanga Ephakathi, eNingizimu-mpumalanga, e-Afrika naseNingizimu Melika njll. Sine-13years yokuthengisa nokuthenga okuphrofeshinali ezingxenyeni ze-Isuzu ekhaya naphesheya kanye nobunikazi bezinhlelo zokuhlola izingxenye ze-elekthronikhi ze-Isuzu zesimanje.Sihlonipha uthishanhloko wethu oyinhloko Wokwethembeka ebhizinisini, ukubeka kuqala enkonzweni futhi sizokwenza konke okusemandleni ethu ukunikeza amakhasimende ethu imikhiqizo yekhwalithi ephezulu kanye nenkonzo enhle kakhulu.

Okumaphakathi kokwenziwa kwe-allopurinol.

Ingenye ye-3-amino-4-substituted pyrazole series.Ingasetshenziswa njengendawo ephakathi ukuze ihlanganise izinhlanganisela eziningi ze-organic ezisebenza kahle ngokwemithi, njenge-allopurinol, enye yochungechunge lwe-pyrazolopyrimidine derivatives, yakamuva kusukela ngo-1963 Kusukela ekusetshenzisweni kwayo emtholampilo, ibiwumuthi oyinhloko wokwelapha i-gout.Njengamanje, zimbalwa izindlela ezaziwayo zokuhlanganisa

I-3-aminopyrazole-4-carboxamide hemisulfate e-China, ikakhulukazi ngokusabela i-malononitrile ne-triethyl orthoformate ukuze kulungiswe i-ethoxymethylene malononitrile, bese kuthi Ukusabela kwe-hydrazine hydrate kukhiqiza i-3-amino-4-cyanopyrazole, ekugcineni isabela nge-asidi egxilile ukukhiqiza i-sulfuric acid.

I-3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), isamba sesivuno ukuhlanganiswa ngale ndlela cishe ku-60% (kubalwa njenge-malononitrile), le ndlela ihilela ukusabela kwezinyathelo ezintathu, izinyathelo zide, futhi ama-reagents asetshenzisiwe, njenge-malononitrile ne-ethoxymethylene malononitrile, anobuthi kakhulu futhi ayabiza.Ngaphezu kwalokho, i-3-aminopyrazole-4 elungiselelwe ngale ndlela -Formamide hemisulfate inombala onzima ukuwususa futhi udinga ukucubungula okwengeziwe, okuyinkimbinkimbi kakhulu.

Kukhona imibiko ezincwadini zakwamanye amazwe kusetshenziswa i-pyridylamide hydrazone kanye ne-ethoxymethylene malononitrile njengezinto zokusetshenziswa ukuze kutholwe i-3-amino-4-cyanopyrazole ngokuhlanganisa kanye ne-cyclization, bese kusabela nge-sulfuric acid egxilile ukuze kutholwe inhlanganisela ehlosiwe (Reuken G Jones. Ukusabela kwama-orthoesters nge i-activemethylene compounds[J]. J Am Chem Soc. 1952,74(5) :4889 4891).Izinto zokusetshenziswa eziyinhloko ezisetshenziswa kule ndlela ziyabiza, isivuno sokusabela asiphezulu, futhi inzuzo yokukhiqizwa kwezimboni iphansi.Kumele kube nzima.

Izinga eliphezulu:I-Enterprise Standard
Ingaphandle:Impushana emhlophe noma ephuzi

Iphakheji:25kg/isigubhu
i-assay (HPLC) okuqukethwe Kukhulu noma kulingana no-98.0%
ubumsulwa (HPLC) okuqukethwe Kukhulu noma kulingana no-99.5%

I-JIN DUN Medical ineIziqu ze-ISO futhi ihlangabezana namazinga okukhiqiza e-GMP, kuqashwe ochwepheshe basekhaya nabangaphandle abanolwazi olunzulu lokuqondisa i-R&D yenkampani.

TECHNOL OGY UBUHLE
●I-High Pressure Catalytic Hydrogenation.I-High Pressure Hydrogenolysis Reaction .Ukusabela kwe-Cryogenic (<-78%C)
● I-Aromatic Heterocyclic Synthesis
●Ukusabela Kabusha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Ukusabela kukaGiignard

Izisetshenziswa

Ilebhu yethu inezinsiza ezihlukahlukene zokuhlola nokuhlola, njenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, i-Differential Scanning Calorimeter (DSC), i-Electron Microscope...

Ithimba le-R&D

I-Jindun Medical ineqembu labasebenzi abangochwepheshe be-R&D, futhi isebenzisa ochwepheshe abaningi bokwenziwa kwezidakamizwa basekhaya nabangaphandle ukuze baqondise i-R&D, okwenza ukuhlanganiswa kwethu kunembe kakhudlwana futhi kusebenze kahle.

Sisize izinkampani ezimbalwa eziphezulu zasekhaya ezithaka imithi, njengeI-Hansoh, i-Hengrui ne-HEC Pharm.Lapha sizokhombisa ingxenye yazo.

Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 110351-94-5

Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 144848-24-8

Ikesi Lesithathu Lokwenza Ngokwezifiso:

Inombolo yeCas: 200636-54-0

1.Enza ngendlela oyifisayo i-New Intermediates noma ama-API.Ngokufanayo nokwabelana kwecala elingenhla, amakhasimende anezidingo ze-Intermediates ethile noma ama-API, futhi awakwazi ukuthola imikhiqizo edingekayo emakethe, lapho-ke singasiza Ukwenza Ngokwezifiso.

2.Ukuthuthukisa Inqubo Yemikhiqizo Emidala.Ithimba lethu lizosiza Ukuthuthukisa futhi lithuthukise ukukhiqiza okunjalo okuyindlela yokusabela endala, izindleko zokukhiqiza ziphezulu, nokusebenza kahle kuphansi.Singahlinzeka ngemibhalo egcwele yokudluliswa kobuchwepheshe kanye nokuthuthukiswa kwenqubo, sisize ikhasimende ngokukhiqiza okuphumelelayo.

Ukusuka kokuhlosiwe kwezidakamizwa kuye kuma-IND, i-JIN DUN Medical ikunikezaizixazululo zomuntu siqu ze-R&D zokuma okukodwa.

I-JIN DUN Medical iphikelela ekwakheni iqembu elinamaphupho, ukwenza imikhiqizo enesizotha, ecophelelayo, eqinile, futhi siphume konke ukuze sibe uzakwethu othembekile nomngane wamakhasimende!

Sinalesi siqubulo, manje sesibe phakathi kwabakhiqizi okungenzeka ukuthi bathuthuke kakhulu kwezobuchwepheshe, abangabizi kakhulu, nabancintisana namanani e-Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Sibheke ngabomvu ukukunikeza ngemikhiqizo yethu maduze nje, futhi uzothola ikhotheshini yethu inengqondo futhi nezinga lemikhiqizo yethu lihle kakhulu!
Isitolo esidayisa yonke impahlaI-China Ibrutinib N-3 kanye nabaPhakathi, Kuze kube manje imikhiqizo yethu isithunyelwe empumalanga Yurophu, eMpumalanga Ephakathi, eNingizimu-mpumalanga, e-Afrika naseNingizimu Melika njll. Sine-13years yokuthengisa nokuthenga okuphrofeshinali ezingxenyeni ze-Isuzu ekhaya naphesheya kanye nobunikazi bezinhlelo zokuhlola izingxenye ze-elekthronikhi ze-Isuzu zesimanje.Sihlonipha uthishanhloko wethu oyinhloko Wokwethembeka ebhizinisini, ukubeka kuqala enkonzweni futhi sizokwenza konke okusemandleni ethu ukunikeza amakhasimende ethu imikhiqizo yekhwalithi ephezulu kanye nenkonzo enhle kakhulu.