I-1,5-Pentanediol diacrylate

I-1,5-Pentanediol diacrylate isetshenziswa njenge-intermediate ye-Cisatracurium besylate.
I-Cisatracurium besylate uhlobo lukasawoti lwe-benzene sulfonate lwe-atracurium.Iwuhlobo lweziphumuli zokwenziwa zokwenziwa ezingezona-depolarizing ezinendima yazo efana ne-tubocurarine.Inesikhathi sokuqala seminithi elingu-1 kanye nesikhathi sobude bemizuzu eyi-15.Umthamo wokwelapha awuthinti inhliziyo, isibindi nokusebenza kwezinso.Futhi ayinayo impahla yokuqongelela.Kungase futhi kubangele ukukhululwa kwe-histamine uma isetshenziswa ngemithamo emikhulu.Ukuze uthole ukuphumula kwemisipha noma ukulawula ukuphefumula okudingekayo ekuhlinzeni, uma kuqhathaniswa nezidakamizwa zamanje zomtholampilo ezinkulu eziphumuza imisipha, i-cisatracurium besylate ayifakwanga i-metabolized ngesibindi noma izinso, futhi inokusimama kwenhliziyo;umphumela wawo wokuphumula kwemisipha unamandla izikhathi ezingu-3 njenge-atracurium ngaphandle kwemiphumela emibi yenhliziyo.I-Cisatracurium besylate isetshenziswa ngokuyinhloko ku-anesthesia ejwayelekile, futhi ingasetshenziswa kabanzi ekungeneni, ekwelapheni ukungasebenzi kahle kwesibindi nezinso, okusetshenziselwa ukuhlinzwa kwenhliziyo nemithambo yegazi kanye neziguli ezikhulile nezezingane.
Uma kuqhathaniswa ne-atracurium, lo mkhiqizo awunayo imiphumela emibi encike kumthamo wokukhishwa kwe-histamine;Nokho, okubi ukuthi iziguli ezinokukhubazeka kwesibindi nezinso kufanele zilawule ngokuqapha.
Kusukela ngo-1996 ngokokuqala ngqa lapho lesi sidakamizwa singena emakethe e-UK, amazwe angaphandle asebenzise kancane kancane ukuze athathe indawo ye-vecuronium ne-atracurium njengento evamile yokuphumula kwemisipha yomtholampilo.