2-deoxy-2,2-difluoro-d-ribofuranose-3,5-dib enzoate

I-2-deoxy-2,2-difluoro-d-ribofuranose-3,5-dib enzoate isetshenziswa njengendawo emaphakathi ye-Gemcitabine .
I-Gemcitabine iyi-analogue ye-pyrimidine nucleotide, eyingxenye yezidakamizwa ezilwa nomdlavuza.Kungavimbela ukuqhubeka kwe-DNA synthesis esikhathini esithile, okungukuthi, isigaba S.Inezici ze-spectrum ebanzi ye-anticancer, indlela eyingqayizivele yokwenza, ubuthi obuphansi, akukho ukumelana okuphambene nezinye izidakamizwa ze-chemotherapeutic futhi akukho ubuthi obuphezulu.Namuhla, i-gemcitabine igunyazwe ukuthi isetshenziswe emazweni angaphezu kuka-90, isiba umuthi womugqa wokuqala wokwelapha umdlavuza wamaphaphu wengqamuzana ongewona omncane kanye “nezinga legolide” lokwelapha umdlavuza wamaphaphu.