3-(1-(Dimethylamino)ethyl]phenol

I-3-(1-(Dimethylamino)ethyl]phenol isetshenziswa njengendawo ephakathi ye-Rivastigmine tartrate.
I-Rivastigmine tartrate iyisidakamizwa se-Alzheimer's rivastigmine, i-rivastigmine isuselwa ku-physostigmine nguNovartis okokuqala ngqa ngempumelelo ithuthukise igama lokuhweba i-Exelon (exelon), i-molecule enesakhiwo se-carbamate, iwuhlobo lwe-amino acid ye-cerebral cholinesterase inhibitor ekhethiwe, futhi ingavimbela. i-acetylcholinesterase ne-butyrylcholinesterase, ama-cholinergic neurons ngokubambezela ukukhululwa kwe-acetylcholine degradation namandla akhuthaza ukuqhutshwa kwe-cholinergic nerve, ingathuthukisa ukuphazamiseka kokusebenza kwengqondo okulamulwa yi-cholinergic, ngaleyo ndlela ithuthukise umsebenzi wokuqonda weziguli ze-Alzheimer's disease.I-Rivastigmine plasma protein binding ibuthakathaka, kalula ngokusebenzisa umgoqo wegazi-ubuchopho, onezinga eliphezulu lokukhetha kobuchopho.Ayisebenzi ngokukhetha kuphela ku-cerebral cortex kanye ne-hippocampus ethinteke kalula, kodwa futhi ivimbela ngokukhethekile uhlobo oluncane olubusayo lwe-AChE ebuchosheni, okuholela ekwehleni kokusebenza kahle kwemiphumela emibi ye-peripheral cholinergic.I-Rivastigmine ku-vivo uhhafu wempilo iyisikhathi esifushane futhi eside sokusebenza.Ngokungafani ne-tacrine, lo mkhiqizo ku-hippocampus kanye ne-cortex ye-G1 enzyme inhibitory effect unamandla.Umtholampilo wokwelapha ukuwohloka komqondo okumaphakathi kuya komaphakathi kwe-Alzheimer's, noma isifo i-Alzheimer's singasoleka njengesifo i-Alzheimer's ngokomtholampilo.