3-Amino-4-pyrazole carbosamide hemisulfate

Okumaphakathi kokwenziwa kwe-allopurinol.

Ingenye ye-3-amino-4-substituted pyrazole series.Ingasetshenziswa njengendawo ephakathi ukuze ihlanganise izinhlanganisela eziningi ze-organic ezisebenza kahle ngokwemithi, njenge-allopurinol, enye yochungechunge lwe-pyrazolopyrimidine derivatives, yakamuva kusukela ngo-1963 Kusukela ekusetshenzisweni kwayo emtholampilo, ibiwumuthi oyinhloko wokwelapha i-gout.Njengamanje, zimbalwa izindlela ezaziwayo zokuhlanganisa

I-3-aminopyrazole-4-carboxamide hemisulfate e-China, ikakhulukazi ngokusabela i-malononitrile ne-triethyl orthoformate ukuze kulungiswe i-ethoxymethylene malononitrile, bese kuthi Ukusabela kwe-hydrazine hydrate kukhiqiza i-3-amino-4-cyanopyrazole, ekugcineni isabela nge-asidi egxilile ukukhiqiza i-sulfuric acid.

I-3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), isamba sesivuno ukuhlanganiswa ngale ndlela cishe ku-60% (kubalwa njenge-malononitrile), le ndlela ihilela ukusabela kwezinyathelo ezintathu, izinyathelo zide, futhi ama-reagents asetshenzisiwe, njenge-malononitrile ne-ethoxymethylene malononitrile, anobuthi kakhulu futhi ayabiza.Ngaphezu kwalokho, i-3-aminopyrazole-4 elungiselelwe ngale ndlela -Formamide hemisulfate inombala onzima ukuwususa futhi udinga ukucubungula okwengeziwe, okuyinkimbinkimbi kakhulu.

Kukhona imibiko ezincwadini zakwamanye amazwe kusetshenziswa i-pyridylamide hydrazone kanye ne-ethoxymethylene malononitrile njengezinto zokusetshenziswa ukuze kutholwe i-3-amino-4-cyanopyrazole ngokuhlanganisa kanye ne-cyclization, bese kusabela nge-sulfuric acid egxilile ukuze kutholwe inhlanganisela ehlosiwe (Reuken G Jones. Ukusabela kwama-orthoesters nge i-activemethylene compounds[J]. J Am Chem Soc. 1952,74(5) :4889 4891).Izinto zokusetshenziswa eziyinhloko ezisetshenziswa kule ndlela ziyabiza, isivuno sokusabela asiphezulu, futhi inzuzo yokukhiqizwa kwezimboni iphansi.Kumele kube nzima.