5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-i-hydrochloride eyodwa

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-one hydrochloride Isithombe Esifakiwe

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-i-hydrochloride eyodwa

Incazelo emfushane:

I-CAS no:115473-15-9

Izakhiwo zamakhemikhali: I-Prasugrel Intermediates

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Isebenzisa

I-5,6,7,7a-tetrahydrothieno (3,2-c) pyridine-2 (4h) -i-hydrochloride eyodwa isetshenziswa njenge-intermediate ye-Prasugrel.
I-Prasugrel iyi-antiplatelet ye-thiophenopyridine eyakhiwe ngu-Eli Lilly kanye no-daiichisankyo, umkhiqizi wemithi waseJapane.Kuyisidakamizwa esandulelayo.Yakha i-molecule esebenzayo ngemva kwe-metabolism nge-cytochrome P450 esibindini futhi ihlangana ne-platelet P2Y12 receptor ukuze isebenze ngokumelene nokuhlanganiswa kweplatelet.Ucwaningo lwezokwelapha luye lwafakazela ukuthi umthamo we-60 mg unomphumela ongcono we-anticoagulant kuno-300 mg ojwayelekile kanye no-600 mg okhushulwe umthamo we-clopidogrel, onganciphisa ubungozi obuphelele bokuhlaselwa yinhliziyo, unhlangothi nokufa ngenxa yesifo senhliziyo ngama-20%, futhi kube nomphumela osheshayo. , umphumela omuhle wokwelapha, ukumelana nezidakamizwa okuhle kanye nokuba khona kwe-bioavailability, kanye nobuthi obuphansi.

Ulayini Womkhiqizo Ohlanganisiwe Wezinsiza

Isitifiketi

I-JIN DUN Medical ineIziqu ze-ISO futhi ihlangabezana namazinga okukhiqiza e-GMP, kuqashwe ochwepheshe basekhaya nabangaphandle abanolwazi olunzulu lokuqondisa i-R&D yenkampani.

Izinzuzo Zokwenza Ngokwezifiso Kwezokwelapha

TECHNOL OGY UBUHLE
●I-High Pressure Catalytic Hydrogenation.I-High Pressure Hydrogenolysis Reaction .Ukusabela kwe-Cryogenic (<-78%C)
● I-Aromatic Heterocyclic Synthesis
●Ukusabela Kabusha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Ukusabela kukaGiignard

I-JIN DUN R&D

Izisetshenziswa

Ilebhu yethu inezinsiza ezihlukahlukene zokuhlola nokuhlola, njenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, i-Differential Scanning Calorimeter (DSC), i-Electron Microscope...

Ithimba le-R&D

I-Jindun Medical ineqembu labasebenzi abangochwepheshe be-R&D, futhi isebenzisa ochwepheshe abaningi bokwenziwa kwezidakamizwa basekhaya nabangaphandle ukuze baqondise i-R&D, okwenza ukuhlanganiswa kwethu kunembe kakhudlwana futhi kusebenze kahle.

Ukwabelana Kwamacala

Sisize izinkampani ezimbalwa eziphezulu zasekhaya ezithaka imithi, njengeI-Hansoh, i-Hengrui ne-HEC Pharm.Lapha sizokhombisa ingxenye yazo.

Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 110351-94-5

Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 144848-24-8

Ikesi Lesithathu Lokwenza Ngokwezifiso:

Inombolo yeCas: 200636-54-0

Imodi Yokubambisana

1.Enza ngendlela oyifisayo i-New Intermediates noma ama-API.Ngokufanayo nokwabelana kwecala elingenhla, amakhasimende anezidingo ze-Intermediates ethile noma ama-API, futhi awakwazi ukuthola imikhiqizo edingekayo emakethe, lapho-ke singasiza Ukwenza Ngokwezifiso.

2.Ukuthuthukisa Inqubo Yemikhiqizo Emidala.Ithimba lethu lizosiza Ukuthuthukisa futhi lithuthukise ukukhiqiza okunjalo okuyindlela yokusabela endala, izindleko zokukhiqiza ziphezulu, nokusebenza kahle kuphansi.Singahlinzeka ngemibhalo egcwele yokudluliswa kobuchwepheshe kanye nokuthuthukiswa kwenqubo, sisize ikhasimende ngokukhiqiza okuphumelelayo.

Ukusuka kokuhlosiwe kwezidakamizwa kuye kuma-IND, i-JIN DUN Medical ikunikezaizixazululo zomuntu siqu ze-R&D zokuma okukodwa.

I-JIN DUN Medical iphikelela ekwakheni iqembu elinamaphupho, ukwenza imikhiqizo enesizotha, ecophelelayo, eqinile, futhi siphume konke ukuze sibe uzakwethu othembekile nomngane wamakhasimende!

Okwedlule: I-Cyclopropyl 2-fluorobenzyl ketone

Olandelayo: 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

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