I-Guanosine
I-Guanosine
I-Guanosine isetshenziswa njenge-Intermediate ye-Valaciclovir.
I-Valacyclovir iyisidakamizwa se-analogue ye-guanine.Isetshenziselwa ukwelashwa kwe-herpes simplex kanye nokutheleleka kwe-herpes zoster ezifweni ezithathelwana ngocansi.Lo mkhiqizo uyisandulela se-acyclovir.Imuncwa ngokushesha ngemva kokuphathwa ngomlomo futhi iguqule ngokushesha ibe i-acyclovir emzimbeni.Umphumela wayo we-antiviral udlalwa yi-acyclovir.Ngemuva kokuthi i-acyclovir ingene kumaseli angenwe yi-herpes, iqhudelana ne-deoxynucleoside yegciwane i-thymidine deoxynucleoside kinase noma i-cell kinase, futhi umuthi ufakwa i-phosphorylated ku-activated acyclic guanosine triphosphate.Njengengxenye engaphansi yokuphindaphinda kwegciwane, i-acyclovir incintisana ne-deoxyguanine triphosphate ye-virus DNA polymerase, evimbela ukuhlanganiswa kwe-DNA yegciwane futhi ibonise umphumela wokunqanda amagciwane.Umsebenzi we-antiviral walo mkhiqizo ku-vivo ungcono kune-acyclovir, futhi inkomba yokwelapha ye-herpes simplex virus uhlobo I nohlobo lwe-II ingu-42.91% no-30.13% ngaphezu kwe-acyclovir ngokulandelanayo.Futhi inomphumela ophezulu wokwelapha ku-varicella zoster virus.
I-JIN DUN Medical ineIziqu ze-ISO futhi ihlangabezana namazinga okukhiqiza e-GMP, kuqashwe ochwepheshe basekhaya nabangaphandle abanolwazi olunzulu lokuqondisa i-R&D yenkampani.
TECHNOL OGY UBUHLE
●I-High Pressure Catalytic Hydrogenation.I-High Pressure Hydrogenolysis Reaction .Ukusabela kwe-Cryogenic (<-78%C)
● I-Aromatic Heterocyclic Synthesis
●Ukusabela Kabusha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Ukusabela kukaGiignard
Izisetshenziswa
Ilebhu yethu inezinsiza ezihlukahlukene zokuhlola nokuhlola, njenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, i-Differential Scanning Calorimeter (DSC), i-Electron Microscope...
Ithimba le-R&D
I-Jindun Medical ineqembu labasebenzi abangochwepheshe be-R&D, futhi isebenzisa ochwepheshe abaningi bokwenziwa kwezidakamizwa basekhaya nabangaphandle ukuze baqondise i-R&D, okwenza ukuhlanganiswa kwethu kunembe kakhudlwana futhi kusebenze kahle.
Sisize izinkampani ezimbalwa eziphezulu zasekhaya ezithaka imithi, njengeI-Hansoh, i-Hengrui ne-HEC Pharm.Lapha sizokhombisa ingxenye yazo.
Ikesi Lokwenza Ngokwezifiso:
Inombolo yeCas: 110351-94-5
Ikesi Lokwenza Ngokwezifiso:
Inombolo yeCas: 144848-24-8
Ikesi Lesithathu Lokwenza Ngokwezifiso:
Inombolo yeCas: 200636-54-0
1.Enza ngendlela oyifisayo i-New Intermediates noma ama-API.Ngokufanayo nokwabelana kwecala elingenhla, amakhasimende anezidingo ze-Intermediates ethile noma ama-API, futhi awakwazi ukuthola imikhiqizo edingekayo emakethe, lapho-ke singasiza Ukwenza Ngokwezifiso.
2.Ukuthuthukisa Inqubo Yemikhiqizo Emidala.Ithimba lethu lizosiza Ukuthuthukisa futhi lithuthukise ukukhiqiza okunjalo okuyindlela yokusabela endala, izindleko zokukhiqiza ziphezulu, nokusebenza kahle kuphansi.Singahlinzeka ngemibhalo egcwele yokudluliswa kobuchwepheshe kanye nokuthuthukiswa kwenqubo, sisize ikhasimende ngokukhiqiza okuphumelelayo.
Ukusuka kokuhlosiwe kwezidakamizwa kuye kuma-IND, i-JIN DUN Medical ikunikezaizixazululo zomuntu siqu ze-R&D zokuma okukodwa.
I-JIN DUN Medical iphikelela ekwakheni iqembu elinamaphupho, ukwenza imikhiqizo enesizotha, ecophelelayo, eqinile, futhi siphume konke ukuze sibe uzakwethu othembekile nomngane wamakhasimende!
