I-Guanosine

I-Guanosine isetshenziswa njenge-Intermediate ye-Valaciclovir.
I-Valacyclovir iyisidakamizwa se-analogue ye-guanine.Isetshenziselwa ukwelashwa kwe-herpes simplex kanye nokutheleleka kwe-herpes zoster ezifweni ezithathelwana ngocansi.Lo mkhiqizo uyisandulela se-acyclovir.Imuncwa ngokushesha ngemva kokuphathwa ngomlomo futhi iguqule ngokushesha ibe i-acyclovir emzimbeni.Umphumela wayo we-antiviral udlalwa yi-acyclovir.Ngemuva kokuthi i-acyclovir ingene kumaseli angenwe yi-herpes, iqhudelana ne-deoxynucleoside yegciwane i-thymidine deoxynucleoside kinase noma i-cell kinase, futhi umuthi ufakwa i-phosphorylated ku-activated acyclic guanosine triphosphate.Njengengxenye engaphansi yokuphindaphinda kwegciwane, i-acyclovir incintisana ne-deoxyguanine triphosphate ye-virus DNA polymerase, evimbela ukuhlanganiswa kwe-DNA yegciwane futhi ibonise umphumela wokunqanda amagciwane.Umsebenzi we-antiviral walo mkhiqizo ku-vivo ungcono kune-acyclovir, futhi inkomba yokwelapha ye-herpes simplex virus uhlobo I nohlobo lwe-II ingu-42.91% no-30.13% ngaphezu kwe-acyclovir ngokulandelanayo.Futhi inomphumela ophezulu wokwelapha ku-varicella zoster virus.