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2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

Incazelo emfushane:

I-CAS no:204205-33-4

Izakhiwo zamakhemikhali: I-Prasugrel Intermediates


Imininingwane Yomkhiqizo

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Isebenzisa

I-2-bromo-2- (2-fluorophenyl) -1-cyclopropylethanone isetshenziswa njengendawo ephakathi ye-Prasugrel.
I-Prasugrel iyi-antiplatelet ye-thiophenopyridine eyakhiwe ngu-Eli Lilly kanye no-daiichisankyo, umkhiqizi wemithi waseJapane.Kuyisidakamizwa esandulelayo.Yakha i-molecule esebenzayo ngemva kwe-metabolism nge-cytochrome P450 esibindini futhi ihlangana ne-platelet P2Y12 receptor ukuze isebenze ngokumelene nokuhlanganiswa kweplatelet.Ucwaningo lwezokwelapha luye lwafakazela ukuthi umthamo we-60 mg unomphumela ongcono we-anticoagulant kuno-300 mg ojwayelekile kanye no-600 mg okhushulwe umthamo we-clopidogrel, onganciphisa ubungozi obuphelele bokuhlaselwa yinhliziyo, unhlangothi nokufa ngenxa yesifo senhliziyo ngama-20%, futhi kube nomphumela osheshayo. , umphumela omuhle wokwelapha, ukumelana nezidakamizwa okuhle kanye ne-bioavailability, kanye nobuthi obuphansi.


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