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3-(1-(Dimethylamino)ethyl]phenol

3-(1-(Dimethylamino)ethyl]phenol

Incazelo emfushane:

I-CAS no:105601-04-5

Izakhiwo zamakhemikhali: I-Rivastigmine tartrate Intermediates


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Isebenzisa

I-3-(1-(Dimethylamino)ethyl]phenol isetshenziswa njengendawo emaphakathi ye-Rivastigmine tartrate.
I-Rivastigmine tartrate iyisidakamizwa se-Alzheimer's rivastigmine, i-rivastigmine isuselwa ku-physostigmine nguNovartis okokuqala ngqa ngempumelelo ithuthukise igama lokuhweba i-Exelon (exelon), i-molecule enesakhiwo se-carbamate, iwuhlobo lwe-amino acid ye-cerebral cholinesterase inhibitor ekhethiwe, futhi ingavimbela. i-acetylcholinesterase ne-butyrylcholinesterase, ama-cholinergic neurons ngokubambezela ukukhululwa kwe-acetylcholine degradation namandla akhuthaza ukuqhutshwa kwe-cholinergic nerve, ingathuthukisa ukuphazamiseka kokusebenza kwengqondo okulamulwa yi-cholinergic, ngaleyo ndlela ithuthukise umsebenzi wokuqonda weziguli ze-Alzheimer's disease.I-Rivastigmine plasma protein binding ibuthakathaka, kalula ngokusebenzisa umgoqo wegazi-ubuchopho, onezinga eliphezulu lokukhetha kobuchopho.Ayisebenzi ngokukhetha kuphela ku-cerebral cortex kanye ne-hippocampus ethinteke kalula, kodwa futhi ivimbela ngokukhethekile uhlobo oluncane olubusayo lwe-AChE ebuchosheni, okuholela ekwehleni kokusebenza kahle kwemiphumela emibi ye-peripheral cholinergic.I-Rivastigmine ku-vivo uhhafu wempilo iyisikhathi esifushane futhi eside sokusebenza.Ngokungafani ne-tacrine, lo mkhiqizo ku-hippocampus kanye ne-cortex ye-G1 enzyme inhibitory effect unamandla.Umtholampilo wokwelapha ukuwohloka komqondo okumaphakathi kuya komaphakathi kwe-Alzheimer's, noma isifo i-Alzheimer's singasoleka njengesifo i-Alzheimer's ngokomtholampilo.

Ulayini Womkhiqizo Ohlanganisiwe Wezinsiza

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Isitifiketi

I-JIN DUN Medical ineIziqu ze-ISO futhi ihlangabezana namazinga okukhiqiza e-GMP, kuqashwe ochwepheshe basekhaya nabangaphandle abanolwazi olunzulu lokuqondisa i-R&D yenkampani.

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Izinzuzo Zokwenza Ngokwezifiso Kwezokwelapha

TECHNOL OGY UBUHLE
●I-High Pressure Catalytic Hydrogenation.I-High Pressure Hydrogenolysis Reaction .Ukusabela kwe-Cryogenic (<-78%C)
● I-Aromatic Heterocyclic Synthesis
●Ukusabela Kabusha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Ukusabela kukaGiignard

I-JIN DUN R&D

Izisetshenziswa

Ilebhu yethu inezinsiza ezihlukahlukene zokuhlola nokuhlola, njenge: NMR (Bruker 400M), HPLC、chiral-HPLC、LC-MS、LC-MS/MS (API 4000),IR,UV,GC,GC,GC-MS, Chromatography, I-Microwave Synthesizer, i-Parallel Synthesizer, i-Differential Scanning Calorimeter (DSC), i-Electron Microscope...

Ithimba le-R&D

I-Jindun Medical ineqembu labasebenzi abangochwepheshe be-R&D, futhi isebenzisa ochwepheshe abaningi bokwenziwa kwezidakamizwa basekhaya nabangaphandle ukuze baqondise i-R&D, okwenza ukuhlanganiswa kwethu kunembe kakhudlwana futhi kusebenze kahle.

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Ukwabelana Kwamacala

Sisize izinkampani ezimbalwa eziphezulu zasekhaya ezithaka imithi, njengeI-Hansoh, i-Hengrui ne-HEC Pharm.Lapha sizokhombisa ingxenye yazo.

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Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 110351-94-5

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Ikesi Lokwenza Ngokwezifiso:

Inombolo yeCas: 144848-24-8

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Ikesi Lesithathu Lokwenza Ngokwezifiso:

Inombolo yeCas: 200636-54-0

Imodi Yokubambisana

1.Enza ngendlela oyifisayo i-New Intermediates noma ama-API.Ngokufanayo nokwabelana kwecala elingenhla, amakhasimende anezidingo ze-Intermediates ethile noma ama-API, futhi awakwazi ukuthola imikhiqizo edingekayo emakethe, lapho-ke singasiza Ukwenza Ngokwezifiso.

2.Ukuthuthukisa Inqubo Yemikhiqizo Emidala.Ithimba lethu lizosiza Ukuthuthukisa futhi lithuthukise ukukhiqiza okunjalo okuyindlela yokusabela endala, izindleko zokukhiqiza ziphezulu, nokusebenza kahle kuphansi.Singahlinzeka ngemibhalo egcwele yokudluliswa kobuchwepheshe kanye nokuthuthukiswa kwenqubo, sisize ikhasimende ngokukhiqiza okuphumelelayo.

Ukusuka kokuhlosiwe kwezidakamizwa kuye kuma-IND, i-JIN DUN Medical ikunikezaizixazululo zomuntu siqu ze-R&D zokuma okukodwa.

I-JIN DUN Medical iphikelela ekwakheni iqembu elinamaphupho, ukwenza imikhiqizo enesizotha, ecophelelayo, eqinile, futhi siphume konke ukuze sibe uzakwethu othembekile nomngane wamakhasimende!


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