4-Methoxybenzylalkohol;ANISALKOHOL;4-methoxy-benzenemethano;

Isiphakathi se-Moxonidine
Ingajabulisa ama-receptor amaphakathi e-α2 futhi ibangele imiphumela ye-antihypertensive, efana ne-clonidine.Izinga lokumuncwa ngomlomo (90%) kanye ne-bioavailability (88%) kokubili kuphezulu, futhi awukho umphumela wokudlula kuqala.Inani eliphakeme kakhulu legazi livela emahoreni angu-1 kuya kwangu-3 ngemva kokuphuza umuthi.Iningi layo likhishwa izinso.I-t1/2 cishe amahora ama-2.Emtholampilo isetshenziselwa umfutho wegazi ophakeme.

Uketshezi olungenambala noma oluphuzi kancane.Iphuzu elincibilikayo lingu-23-25.5 ° C, indawo yokubilisa ingu-159 ° C, ukuminyana okuhlobene ngu-1.113 (15/15 ° C), futhi inkomba ye-refractive ingu-1.5442.Incibilika kalula otshwaleni ne-ether, cishe ayincibiliki emanzini.

Lo mkhiqizo unephunga elimnandi le-fennel elimnandi futhi uvame ukusetshenziswa ekulungiseleleni i-jasmine, i-lilac nezinye i-flavour, futhi ilungele ukulungiswa kwamakha.Lo mkhiqizo uyisinongo esidliwayo esivunyelwe i-GB2760-86 yezwe lami.Isetshenziselwa kakhulu ukulungisa ama-flavour afana ne-vanilla, ushokoledi, ukhokho, i-almond, nepentshisi.Ibuye isetshenziswe ku-organic synthesis nanjenge-solvent.

Ngokunciphisa i-anisaldehyde.I-Cannizzaro isabela ne-anise, i-formaldehyde ne-sodium hydroxide ku-ethanol ukukhiqiza utshwala be-p-methoxybenzyl.

Ngemva kokuba i-ethanol isitholakele ngokuhluzwa, ungqimba lwamafutha olutholwe ukusabela lukhishwa nge-benzene, lwenziwe i-asidi ngokungeza i-acetic acid, bese luncishiswa nge-sodium bicarbonate lube yi-alkaline ebuthakathaka.Ngemva kokugeza ngamanzi ukuze ingathathi hlangothi, i-benzene ibuye itholakale ngokuhluzwa, futhi okusele kufakwe ku-vacuum distillation ukuze kutholwe i-p-methoxy Benzyl alcohol.

Isebenza ngokuvuselela ama-presynaptic α2-receptors aphakathi.Umphumela wayo we-antihypertensive uyafana nalowo we-calcium antagonist nifedipine kanye ne-ACE inhibitor captopril.Isetshenziselwa i-hypertension ebalulekile.