5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-one

I-5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4h)-enye isetshenziswa njengendawo ephakathi I-Prasugrel .
I-Prasugrel iyi-antiplatelet ye-thiophenopyridine eyakhiwe ngu-Eli Lilly kanye no-daiichisankyo, umkhiqizi wemithi waseJapane.Kuyisidakamizwa esandulelayo.Yakha i-molecule esebenzayo ngemva kwe-metabolism nge-cytochrome P450 esibindini futhi ihlangana ne-platelet P2Y12 receptor ukuze isebenze ngokumelene nokuhlanganiswa kweplatelet.Ucwaningo lwezokwelapha luye lwafakazela ukuthi umthamo we-60 mg unomphumela ongcono we-anticoagulant kuno-300 mg ojwayelekile kanye no-600 mg okhushulwe umthamo we-clopidogrel, onganciphisa ubungozi obuphelele bokuhlaselwa yinhliziyo, unhlangothi nokufa ngenxa yesifo senhliziyo ngama-20%, futhi kube nomphumela osheshayo. , umphumela omuhle wokwelapha, ukumelana nezidakamizwa okuhle kanye ne-bioavailability, kanye nobuthi obuphansi.