5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-i-hydrochloride eyodwa

I-5,6,7,7a-tetrahydrothieno (3,2-c) pyridine-2 (4h) -i-hydrochloride eyodwa isetshenziswa njenge-intermediate ye-Prasugrel.

I-Prasugrel iyi-antiplatelet ye-thiophenopyridine eyakhiwe ngu-Eli Lilly kanye no-daiichisankyo, umkhiqizi wemithi waseJapane.Kuyisidakamizwa esandulelayo.Yakha i-molecule esebenzayo ngemva kwe-metabolism nge-cytochrome P450 esibindini futhi ihlangana ne-platelet P2Y12 receptor ukuze isebenze ngokumelene nokuhlanganiswa kweplatelet.Ucwaningo lwezokwelapha luye lwafakazela ukuthi umthamo we-60 mg unomphumela ongcono we-anticoagulant kuno-300 mg ojwayelekile kanye no-600 mg okhushulwe umthamo we-clopidogrel, onganciphisa ubungozi obuphelele bokuhlaselwa yinhliziyo, unhlangothi nokufa ngenxa yesifo senhliziyo ngama-20%, futhi kube nomphumela osheshayo. , umphumela omuhle wokwelapha, ukumelana nezidakamizwa okuhle kanye ne-bioavailability, kanye nobuthi obuphansi.