2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylaMino) propoxy]phenyl]

Isetshenziswa emtholampilo ku-hyperuricemia eyinhloko neyesibili, ikakhulukazi ezigulini ezine-hyperuricemia, kanye nasezigulini ezinokwehluleka kwezinso, nasezigulini ezine-gout ephindaphindiwe noma engapheli, kanye nasezigulini ezine-Hyperuricemia.Isetshenziswa ezigulini ezine-Gouty nephropathy ukunciphisa izimpawu nokunciphisa ukwakheka kwamatshe e-uric acid ezinso;amatshe e-gout;esetshenziswa ku-uric acid ezinso zamatshe kanye nesifo sezinso se-uric acid.

Umuthi omusha wokulwa nokungezwani komzimba ne-arrhythmic i-Atrial fibrillation (AF) yisifo esingase sibe yingozi empilweni.Ngenxa yokuguga kwenani labantu, izigameko zomhlaba kanye nokufa kwe-atrial fibrillation ziyanda, futhi sekuyinkinga entsha yezempilo yomphakathi.Kuneziguli eziyizigidi ezingu-2.5 ezine-atrial fibrillation e-United States kanye nezigidi ezingu-4.5 e-European Union.Ngokwezibalo, ukusabalala kwe-atrial fibrillation kubantu abangaphezu kweminyaka engama-30 ezweni lami kungu-0.77%, okwandayo ngeminyaka, kanti abesilisa bangaphezulu kwabesifazane (0.9%:0.7%).Izifo ezibangela i-atrial fibrillation ikakhulukazi zihlanganisa umfutho wegazi ophakeme, isifo senhliziyo, isifo senhliziyo, isifo senhliziyo esivuleka ngokuzenzakalelayo, nokuhluleka kwenhliziyo.Uphawu oluyinhloko lweziguli ezine-fibrillation ye-atrial yizinga elingavamile le-ventricular, futhi ukulawulwa kwenhliziyo kuthatha indawo ethile ekwelapheni okunamandla nokugcinwa kwezimpawu.I-Amiodarone idlala indima enhle ekulawuleni ukushaya kwenhliziyo nokubuyisela isigqi se-sinus, kodwa imiphumela emibi yezitho ezihlosiwe ezihlobene nengxenye ye-iodine esakhiweni sayo ikhawulela ukusebenza kwayo emtholampilo, njengokulimala kwamaphaphu, igilo, nesibindi.Ukusabela okubi okubalulwe ngenhla kanye nesakhiwo sayo I-iodine in ihlobene eduze.Isidakamizwa esisha se-antiarrhythmic i-Dronedarone (i-Dronedarone) satholwa ngokulungisa ukwakheka kwe-amiodarone.I-Dronedarone inezinto ze-electrophysiological ezifana ne-amiodarone, kodwa ayinayo iodine esakhiweni sayo, ngakho-ke ingagwema imiphumela emibi kakhulu ye-extra-cardiac ebangelwa i-iodine Chemicalbook.I-Dronedarone yagunyazwa ukumakethwa yi-US Food and Drug Administration (FDA) ngoJulayi 2009, futhi yavunyelwa ukumakethwa e-European Union ngo-2009. Futhi iyisidakamizwa sokuqala esisha se-antiarrhythmic esivunyelwe e-European Union eminyakeni engu-10.I-Dronedarone i-N-[2-butyl-3-[4-[3-(dibutylamino)) propoxy]phenyl]-5-benzofuranyl]-methanesulfonamide, okuwukunciphisa okuphuma ku-benzofuran okutholwe ngokuguqulwa kwesakhiwo se-amiodarone, okungeyona ukusabela okubi kwenhliziyo.Isusa i-athomu ye-iodine ku-amiodarone ukunciphisa ubuthi begilo nezinye izitho;yengeza iqembu le-methylsulfonyl ohlangothini lwe-benzofuran ukunciphisa i-lipophilicity, ngaleyo ndlela kufinyezwe isigamu sempilo yomuthi futhi kunciphise umphumela wokuqoqwa kwezicubu kanye nokwenzeka kwesidakamizwa se-Neurotoxicity.Kokubili inguqulo yango-2011 yase-US kanye nenguqulo ka-2010 yaseYurophu ye-Atrial Fibrillation Guidelines incoma i-dronedarone yokwelashwa kwe-atrial fibrillation.I-Dronedarone iphephile futhi iyasebenza ekwelapheni izinga le-ventricular nokugcina izinga le-sinus ezigulini ezihlukahlukene ngaphandle kwe-AF enzima.Kungaba umuthi osebenzayo wokushintsha i-amiodarone.I-Dronedarone nayo inganciphisa ukufa kweziguli ezine-AF ngisho neziguli ezine-AF eziphikelelayo.Ngakho-ke, kulindeleke ukuthi kube umuthi womugqa wokuqala weziguli ezine-AF ngaphandle kokuhluleka kwenhliziyo okukhulu.Ngaphezu kwalokho, ukusetshenziswa kwama-anticoagulants ezigulini ezisengozini enkulu ye-AF kunenzuzo ekusebenziseni i-dronedarone.